Publications
Thanks to the financial support of the Synapsis Foundation, numerous new insights were gained for the fight against dementia diseases. Below you will find some selected scientific publications from the supported projects:
Protein fibril aggregation on red blood cells a potential biomarker to distinguish neurodegenerative diseases from healthy aging
Dr. Peter Nirmalraj, EMPA
Cell-to-cell transmitted alpha-synuclein recapitulates experimental Parkinson’s disease
Prof. Dr. Roland Riek, PhD, ETH Zurich
Transmission-selective muscle pathology induced by the active propagation of mutant huntingtin across the human neuromuscular synapse
Amandine Grimm, PhD, Project leader, Research Platform Molecular & Cognitive Neuroscience, Department of Biomedicine, University of Basel, Basel, Switzerland
Deep Learning-Assisted Single-Molecule Detection of Protein Post-translational Modifications with a Biological Nanopore
Chan Cao, PhD, EPFL Laboratory for Biomolecular Modeling
Unlocking Novel Therapies: Cyclic Peptide Design for Amyloidogenic Targets through Synergies of Experiments, Simulations, and Machine Learning
Dr. Iona-Mariuca Ilie, PhD, University Amsterdam
ER-mitochondria contacts and cholesterol metabolism are disrupted by disease-associated tau protein
Amandine Grimm, PhD, Project leader, Research Platform Molecular & Cognitive Neuroscience, Department of Biomedicine, University of Basel, Basel, Switzerland
Tau protein binds to the P53 E3 ubiquitin ligase MDM2
Stéphanie Papin, PhD, AC Immune SA, Lausanne, Switzerland
Open pathways for cerebrospinal fluid outflow at the cribriform plate along the olfactory nerves
Steven Proulx, PhD, Group Leader, Theodor Kocher Institute (TKI), University of Bern, Bern, Switzerland
Tau Transfer via Extracellular Vesicles Disturbs the Astrocytic Mitochondrial System
Nicolas Toni, PhD, Group Leader, Département des neurosciences fondamentales, Université de Lausanne, Lausanne, Switzerland
Overexpression of UCP4 in astrocytic mitochondria prevents multilevel dysfunctions in a mouse model of Alzheimer's disease
Jean-Yves CHATTON, PhD, Associate professor, Director, Department of Fundamental Neurosciences,University of Lausanne, Lausanne, Switzerland
«Early β-amyloid accumulation in the brain is associated with peripheral T cell alterations»
Christoph Gericke, Dr. sc. nat., Institute for Regenerative Medicine - IREM, University of Zurich, Schlieren, Switzerland & Maria Teresa Ferretti, PhD, Institute for Regenerative Medicine - IREM, University of Zurich, Schlieren, Switzerland
Multi-Dimensional Structure and Dynamics Landscape of Proteins in Mammalian Cells Revealed by In-Cell NMR
Prof. Dr. Roland Riek, PhD, ETH Zurich
Protein structure determination in human cells by in-cell NMR and a reporter system to optimize protein delivery or transexpression
Prof. Dr. Roland Riek, PhD, ETH Zurich
Automatized online prediction of slow-wave peaks during non- rapid eye movement sleep in young and old individuals: Why we should not always rely on amplitude thresholds
Marc Alain Züst et.al., Automatized online prediction of slow-wave peaks during non- rapid eye movement sleep in young and old individuals: Why we should not always rely on amplitude thresholds, Journal of Sleep Research (2022), 00:e13584
Low Subicular Volume as an Indicator of Dementia-Risk Susceptibility in Old Age
Paul G. Unschuld et.al., Low Subicular Volume as an Indicator of Dementia-Risk Susceptibility in Old Age, Front. Aging Neuroscience (2022) 14:811146
Impairments in Brain Bioenergetics in Aging and Tau Pathology: A Chicken and Egg Situation?
Amandine Grimm, Impairments in Brain Bioenergetics in Aging and Tau Pathology: A Chicken and Egg Situation?, Cells (2021) 10, 253
Sequestration within biomolecular condensates inhibits Aß-42 amyloid formation
Paolo Arosio et.al, Sequestration within biomolecular condensates inhibits Aß-42 amyloid formation, Chemical Science (2021) 12, p4373-4382
Slow-wave sleep affects synucleinopathy and regulates proteostatic processes in mouse models of Parkinson’s disease
Daniela Noain et.al., Slow-wave sleep affects synucleinopathy and regulates proteostatic processes in mouse models of Parkinson’s disease, Science Transational Medicine (2021), 13 eabe7099
Brain circuits signaling the absence of emotion in body language
Arseny A. Sokolov et.al., Brain circuits signaling the absence of emotion in body language, PNAS (2020) 117 :20868–20873
Comprehensive analysis of PM20D1 QTL in Alzheimer’s disease
Johannes Gräff et. al. Comprehensive analysis of PM20D1 QTL in Alzheimer’s disease, Clinical Epigenetics (2020) 12:20
Detection of cerebral tauopathy in P301L mice using high-resolution large-field multifocal illumination fluorescence microscopy
Ruiqing Ni, Detection of cerebral tauopathy in P301L mice using high-resolution large-field multifocal illumination fluorescence microscopy, Biomedical Optics Express (2020) 11-9, p4989ff
Oligomeric Forms of Human Amyloid-Beta(1–42) Inhibit Antigen Presentation
Christoph Gericke et.al., Oligomeric Forms of Human Amyloid-Beta(1–42) Inhibit Antigen Presentation, Frontiers in Immunology (2020) 11:1029.
Tau accumulation in astrocytes of the dentate gyrus induces neuronal dysfunction and memory deficits in Alzheimer’s disease
Kevin Richetin et.al., Tau accumulation in astrocytes of the dentate gyrus induces neuronal dysfunction and memory deficits in Alzheimer’s disease, Nature Neuroscience (2020), 23:1567–1579
Tau affects P53 function and cell fate during the DNA damage response
Paolo Paganetti et.al., Tau affects P53 function and cell fate during the DNA damage response, Communications Biology (2020) 3(1):245
Clearance of cerebrospinal fluid from the sacral spine through lymphatic vessels
Steven T. Proulx, Clearance of cerebrospinal fluid from the sacral spine through lymphatic vessels, J. Exp. Med., (2019), 2016-11 p2492–2502
Ossified blood vessels in primary familial brain calcification elicit a neurotoxic astrocyte response
Annika Keller, Ossified blood vessels in primary familial brain calcification elicit a neurotoxic astrocyte response, Brain, (2019) 14-4, p885–902
Simulation Studies of Amyloidogenic Polypeptides and Their Aggregates
Amedeo Caflisch et.al., Simulation Studies of Amyloidogenic Polypeptides and Their Aggregates, Chemical Reviews, (2019) 119-12, p6956–6993
Extravascular CD3+ T Cells in Brains of Alzheimer Disease Patients Correlate with Tau but Not with Amyloid Pathology: An Immunohistochemical Study
Maria Teresa Ferretti et.al., Extravascular CD3+ T Cells in Brains of Alzheimer Disease Patients Correlate with Tau but Not with Amyloid Pathology: An Immunohistochemical Study, Neurodegenerative Diseases (2018)18:49–56
PM20D1 is a quantitative trait locus associated with Alzheimer’s disease
Jose V. Sanchez-Mut, PM20D1 is a quantitative trait locus associated with Alzheimer’s disease, Nature Medicine (2018), 598-24, p598–603
TDP-43 Depletion in Microglia Promotes Amyloid Clearance but Also Induces Synapse Loss
Rosa C. Paolicelli, TDP-43 Depletion in Microglia Promotes Amyloid Clearance but Also Induces Synapse Loss, Neuron (2017) 95-2, p297-308